SOD1 and amyotrophic lateral sclerosis: Some 220 mutations that is predicted to alter the SOD1 amino acid sequence have been found since 1993 (https://alsod.ac.uk).3 21 For only about a quarter of these have causation for ALS been proved by cosegregation in large pedigrees with a significant LOD score, by statistical–epidemiological means or by overexpression in a transgenic rodent model that develops an ALS-like disease.