These often delayed the ALS diagnosis but are in character no different from the sensory symptoms reported in some patients with the p.Ala5Val, p.Ala90Val, p.Asp91Ala and p.Gly128Arg SOD1 mutations.15 16 28 29 In summary, the phenotypes observed closely matches what has been reported for fALS SOD1. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.