Higher LDL (HR 1.35, 95% CI 1.09 to 1.68, p=0.007, adjusted p=0.021) or apoB (HR 1.23, 95% CI 1.00 to 1.25, p=0.050, adjusted p=0.129) were associated with an increased risk of ALS. This evidence concerns the gene APOB and amyotrophic lateral sclerosis.