The Apolipoprotein-related MOrtality RISk study (AMORIS) identified an association between higher LDL:HDL and increased risk of developing ALS.15 The increased risk was driven primarily by higher levels of LDL and apoB, whereas in this study the associations mainly reflect relatively lower levels of HDL (or apoA1) measured at enrolment in those subsequently developing ALS, although higher LDL (or apoB) was strongly associated with an increased risk of ALS in a subset of multivariate models. This evidence concerns the gene APOB and amyotrophic lateral sclerosis.