APOA1 and amyotrophic lateral sclerosis: Higher HDL (HR 0.81, 95% CI 0.67 to 0.97, p=0.022, adjusted p=0.123) and higher apoA1 (HR 0.83, 95% CI 0.70 to 0.99, p=0.043, adjusted p=0.157) were associated with a reduced risk of ALS (table 2).