In accordance, the recruitment of il-10+ regulatory T cells to the lungs of H. polygyrus-infected mice was dependent on ffar3, and H. polygyrus-evoked changes in the gut microbiome that reduced obesity in high-fat diet-fed mice were dependent of signal transducer and activator of transcription (STAT)-6 (i.e., il-4/il-13 signaling) [50]. Here, IL4 is linked to obesity due to melanocortin 4 receptor deficiency.