M2 macrophages secrete pro-tumorigenic, pro-angiogenic, and immunosuppressive factors such as IL10, TGFβ, and VEGFA; whereas M1 macrophages produce pro-inflammatory cytokines such as TNFα, IL1, IL12, and IFNγ, and reactive oxygen species, which prevent tumor growth [41]. The gene discussed is VEGFA; the disease is neoplasm.