STAT3 and hepatocellular carcinoma: It was demonstrated that the phosphorylation of HSP27 at S78/S82 site and JNK1/2/3 was enhanced and that of mTOR, ERK1/2, PRAS40 at T246 site and STAT3 at S727 site were decreased in shPOLQ cells (Fig. 6A–C), indicating the potential involvement of these pathways in the regulation of HCC by POLQ.