Here, we found that SLC2A1-AS1 depletion suppressed cell migration and invasion in ESCC cells (Fig. 4A, B and C), coupled with increased E-cadherin protein expression and reduced N-cadherin and Vimentin protein expressions (Fig. 4D and E), whereas SLC2A1-AS1 overexpression promoted cell migration and invasion in ESCC cells (Supplementary Fig. 4 A, B and C), accompanying reduced E-cadherin protein expression and increased N-cadherin and Vimentin protein expressions (Supplementary Fig. 4 D and E). The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.