We found SLC2A1-AS1 was highly expressed in ESCC tissues and cells, and its overexpression was tightly correlated with TNM stage, lymph node metastasis and poor prognosis of ESCC patients, which was similar to the study reported in LUAD [33], but was inconsistent with the data previously reported in HCC [34]. Here, SLC2A1 is linked to esophageal squamous cell carcinoma.