The PACS1-NDD series had a much higher prevalence of several medical conditions including musculoskeletal disorders (population 4% vs PACS1-NDD: 62%), gastrointestinal disorders (population: 5% vs PACS1-NDD: 41%), cardiac disorders (population: < 1% vs PACS1-NDD: 32%), and endocrine disorders(population 1% vs PACS1-NDD: 26%) [23]. This evidence concerns the gene PACS1 and musculoskeletal system disorder.