CALR and neoplasm: In order to determine if CRT/E7(N53S) can generate a therapeutic antitumor effect against the spontaneous HPV16-E6E7-expressing oral tumor, HLA-A2 (AAD) transgenic mice were injected with HPV16-E6E7-expressing oral tumor using HPV16-E6/E7, NRasG12V, SB100, and luciferase reporter constructs as described in Fig. 4 to create the tumor model.