Although CRT/E7(N53S) is able to control wild-type E7 expressing tumor in HLA-A2 (AAD) transgenic mice, the mutated E7 vaccine does not generate an immune response against HPV16 E7(aa49-57) epitope in CRT/E7(N53S) vaccinated HLA-A2 transgenic mice (Figs. 2 and 3). The gene discussed is CALR; the disease is neoplasm.