While vaccination of HLA-A2(AAD) transgenic mice with CRT/E7 DNA could not generate HLA-A2 restricted E7-specific CD8 + T cell mediated immune responses and vaccination with CRT/E7(N53S) DNA vaccine could not generate detectable murine H-2Db restricted E7 specific CD8 + T cell mediated immune responses, vaccination of wild type E7-expressing spontaneous oral tumor bearing mice with CRT/E7(N53S) DNA vaccine in HLA-A2 (AAD) transgenic mice was capable of controlling tumor growth and results in prolonged survival for tumor bearing mice compared to empty vector (Fig. 5). The gene discussed is CALR; the disease is neoplasm.