CR-1 regulates signaling pathways such as Wnt/β-catenin, AKT, Stat3, MAPK/ERK, TGF-β and Notch [12–15, 22, 25, 55, 56], all of which are implicated in hepatocarcinogenesis, HCC progression, and poor prognosis [9, 10, 57–59]. Here, TGFB1 is linked to hepatocellular carcinoma.