For example, overexpression of Cripto-1 transgene in the mammary glands of MMTV-CR-1 or WAP-CR-1 transgenic mice promoted mammary epithelial hyperplasia and adenocarcinoma [15, 20] and leiomyosarcoma of the uterus in the MMTV-CR-1 transgenic mice [21]. This evidence concerns the gene CR1 and adenocarcinoma.