In two GEO datasets (GEO14520 and GEO25097), the expression levels of G0S2, PDK4, Plk2, Plk3 and Tff2 in the patient HCC tissues were significantly lower than their matched adjacent normal liver tissues (Figure 7A, 7B), whereas, Srebf1 expression was upregulated in HCC tissues compared to the matched normal liver tissues (Figure 7B). The gene discussed is TFF2; the disease is hepatocellular carcinoma.