Transgene-enforced overexpression of SAT1 accelerates aging in mice [74] as it enhances carcinogenesis [75, 76], while its knockout protects against liver and kidney ischemia-reperfusion damage [77], CCL4-induced acute liver injury [78], and endotoxin- or cisplatin-induced acute kidney injury [79, 80]. This evidence concerns the gene CCL4 and acute kidney injury.