Notably, we found that rs1064524 in ITGAL [minor allele frequency (MAF)Biobank = 4.3%] associated with phenome-wide significance (Bonferroni correction) with pleural plaques (β = 1.9; P = 7.5 × 10−7) and diseases of the thymus (β = 1.5; P = 4.5 × 10−5). Here, ITGAL is linked to pleural disorder.