Likewise, upon immunization with Lm, CD8+ TM cells induced after VSV vaccination also induced a rapid and coordinated burst of Ag-dependent chemokines and Ag-independent IFNγ accumulation, peaking at ~16 hours after challenge infection, with 40 to 60% of chemokine/IFNγ+ OT-I TM cells. The gene discussed is CD8A; the disease is infection.