We previously showed that CD8+ TM cell–mediated control of Lm growth during recall infection occurs within only a few hours (~6 to 8 hours) and correlates with their rapid localization with clustered CCR2+Ly6C+ monocytes and neutrophils in the splenic red pulp (RP) of infected mice, at portal of bacterial entry (20, 27, 38). The gene discussed is CD8A; the disease is infection.