Since the association of obesity and adipokines with metabolic disturbances were reported before, and also there is a notable relationship between obesity, dietary pattern, and depressive symptoms [9–11], here, we investigated the possible role of Galectin-3, TGF-β, and PAI-1 in mediating the association between adherence to LCD and depressive symptoms among overweight and obese women. Here, LGALS3 is linked to obesity due to melanocortin 4 receptor deficiency.