Specifically, two proteins from the HLA families and one from the SLC families have been implicated in AD through meta-analyses of large GWAS and brain DNA-methylation association analysis.[9,113] We first examined their single-gene analysis results and observed that none of them was significant using the AMP-AD dataset (p = 4.74e-01; 2.14e-01, for HLA-A and SLC26A7, respectively). Here, HLA-A is linked to Alzheimer disease.