We chose this pathway because it represented one of the earliest morphological changes in AD development, and multiple AD risk factors, predominantly through common SNPs, have been implicated specifically in this pathway with genome-wide significance, including BIN1, CD2AP, PICALM, RIN3, and SORL1.[9,12,18,19,21,22,116] Our results demonstrated additional correlation between rare variants in the endocytic pathway and AD. The gene discussed is PICALM; the disease is Alzheimer disease.