It has been reported that the spindle cells in FDCS are positive for CD68[8,19] and EGFR[4,20] on immunohistochemical staining; additionally, the key role played by EGFR in the tumorigenesis of FDCS by driving the survival and proliferation of tumor cells has been previously verified.[20] In the present case, immunohistochemical staining revealed positivity for CD68 and EGFR, although no EGFR mutation was found. The gene discussed is CD68; the disease is neoplasm.