In conclusion, we reported here, for the first time, that the FKBP5 SNPs (rs1043805, rs3800373, rs9296158, rs7748266, rs136078,0 rs9470080, and rs2817035) and haplotypes were not associated with the susceptibility of MDD and treatment response to antidepressants in Han Chinese. This evidence concerns the gene FKBP5 and major depressive disorder.