FKBP5 and major depressive disorder: For example, a cross-sectional study of 4639 samples reported that all minor alleles of rs9394309, rs9470080, rs7748266, and rs1360780 were not only associated with decreased levels of cortisol, but also with an increased likelihood of depressive symptoms.[43] This circumstantial evidence suggests that FKBP5 SNPs hold some promise as candidate markers for the pathophysiology of depression.