TLRs activate NF-κB, MAPK signaling pathway, release NF-κB, IFN – α, and other factors, up regulate the expression of costimulatory molecules on the surface of antigen-presenting cells, initiate natural immune response, activate nonspecific immune response, participate in the process of immune defense, and play an important role in the formation and development of inflammation and tumor. Here, IFNA1 is linked to neoplasm.