Future studies on the biological function and mechanism of IGF2-AS/miR-520h/CDKN1A axis in HCC carcinogenesis and distal organ metastasis should be performed in vivo, using the HCC orthotopic xenograft model mice with distal organ metastasis, before the clinical translational research was carried out. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.