For investigating the biological function of IGF2-AS in HCC oncogenesis and progression, we first extracted IGF2-AS expression profile in tissues of HCC patients from TCGA (Figure 1a) and GEPIA (Figure 1b) databases, which revealed a significantly down-regulated IGF2-AS expression in tumors tissues than in normal tissues of HCC patients. The gene discussed is IGF2; the disease is hepatocellular carcinoma.