HES1 and cardiovascular disorder: Based on the annotation analyses for these 23 genes (Supplementary Table 7) and the above-mentioned KEGG enrichment analysis, we selected CCL4L2/IL15RA/IL32 (three genes related to cytokine-cytokine receptor interaction)/TIE1 (an angiogenesis-related gene), DKK1 (a gene involved in WNT1 signaling)/DMD (a gene implicated in viral myocarditis)/GCNT1 (a gene related to metabolic pathways and cardiovascular disease)/Gypc (a cardiovascular disease-related gene)/Hes1 (an unannotated gene) for further investigations.