The results showed that expression of ERMN (R = −0.32, P <0.05), MOBP (R = −0.32, P <0.05), PLP1 (R = −0.37, P <0.05), and OPALIN (R = −0.35, P <0.05) were significantly and negatively associated with KPS in older GBM patients in TCGA, whereas the expression of other hub genes had no significant relationship with KPS in older GBM patients in TCGA (Figure 6). The gene discussed is PLP1; the disease is glioblastoma.