It was revealed that Ermin (ERMN), myelin-associated oligodendrocyte basic protein (MOBP), proteolipid protein 1 (PLP1), and oligodendrocytic myelin paranodal and inner loop protein (OPALIN) were present in the modules associated with Karnofsky performance status (KPS) score and upregulated in the GBM tissues provided by older patients with low KPS scores. The gene discussed is OPALIN; the disease is glioblastoma.