Our data are similar to reports of necroptosis in neurodegeneration where neurons were identified as the major cell type that express P-MLKL in the brains of patients with Alzheimer’s disease [15], multiple sclerosis [53], Parkinson’s disease [18], ischemic brain [73, 74], and in Japanese encephalitis virus infection [75]. The gene discussed is MLKL; the disease is early-onset autosomal dominant Alzheimer disease.