Similarly, inhibition of necroptosis using Nec-1s, an allosteric inhibitor of RIPK1, has been shown to reduce neuroinflammation in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis [15, 18, 21, 22]. Here, RIPK1 is linked to amyotrophic lateral sclerosis.