MLKL and early-onset autosomal dominant Alzheimer disease: For example, the hippocampus and temporal gyrus were identified as the regions that had the highest expression of P-MLKL in Alzheimer’s disease [15], increased expression of P-MLKL was reported in the cortical layers II–III in multiple sclerosis [53], and P-MLKL expression was found in substantia nigra in Parkinson’s disease [18].