The European Association of Urology (EAU) and European Society of Medical Oncology (ESMO) recommend Atezolizumab, an inhibitor of programmed death-ligand 1 (PD-L1), as an alternative to carboplatin-based chemotherapy for cisplatin-ineligible patients with treatment-naive locally advanced or metastatic bladder cancer (BC) [1]. This evidence concerns the gene CD274 and breast cancer.