For example, it is known that cardiac involvement in the form of a cardiomyopathy is more frequent in patients with beta-sarcoglycanopathy, than in patients with alpha or gamma-sarcoglycanopathy.8,49,57,59 Loss of delta-sarcoglycan is associated with cardiomyopathy is several preclinical animal models. This evidence concerns the gene SGCD and autosomal recessive limb-girdle muscular dystrophy type 2C.