Similarly, recent studies have shown that IL-25, a member of the IL-17 family, can promote M2 macrophage polarization and regulate enzymes associated with promoting lipolysis and inhibiting lipogenesis in macrophages and adipocytes, thereby promoting lipid metabolism and energy production, alleviating lipid accumulation in the liver and AT and reducing the increase of obesity [36]. The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.