The researchers reported that HFD-induced obesity induced a series of proteins, such as the MIPs lipopolysaccharide binding protein (LBP), melatonin-related receptor (GPR50) and phospholipid transfer protein (PLTP), in VA; these proteins are associated with obesity-related chronic inflammation and metabolic disorders. Here, PLTP is linked to obesity due to melanocortin 4 receptor deficiency.