Wang J et al. found that the LOC441461 carcinogenic role of in colorectal cancer development was related to MLC and LIMK1 phosphorylation of via RhoA/ROCK signaling pathway [35].The lncRNA, NBR2, increased AMPK kinase activity under stress conditions, affected protein expression in tumor cells, and promoted tumor development [36]. The gene discussed is LIMK1; the disease is colorectal cancer.