The highest correlated genes included TPPP2, a gene regulating tubulin polymerization implicated in male infertility (Zhu et al., 2019), FAM71E1, being predominantly expressed in testes (Kwon et al., 2017), SPATA42, a long non-coding RNA implicated in azoospermia (Bo et al., 2020), MTFR1, a gene regulating mitochondrial fission, and MLF1, an oncogene regulated in Drosophila testes (Singh et al., 2016; Figure 8A, Figure 8—figure supplement 1). This evidence concerns the gene TPPP2 and male infertility.