In the present study, based on The Cancer Genome Atlas (TCGA) database, we aimed to analyze the expression levels of ZFC3H1 and its target genes in PRAD, explore the role of ZFC3H1 in PRAD, and finally determine whether ZFC3H1 could provide a reference to evaluate PRAD prognosis and treatment by detecting its influence on the migration and invasion of PRAD cells. The gene discussed is ZFC3H1; the disease is prostate adenocarcinoma.