UCP1 and obesity due to melanocortin 4 receptor deficiency: In contrast with WAT, brown adipose tissue (BAT), which owns multi‐ocular lipid droplets and numerous mitochondria, can uncouple substrate oxidation from ATP production into heat by utilizing uncoupling protein 1 (UCP1).[3] Distribution of BAT was discovered by PET‐CT in adult human, and the reverse correlation of BAT activity with body mass index (BMI) make the process of BAT activation become the promising anti‐obesity therapeutic target.[4, 5]