CFTR and cystic fibrosis: We have shown previously that acute basolateral WT SMase treatment decreases transepithelial CFTR currents in non‐CF bronchial epithelial cells (nHBEs), tracheal epithelial cells (nHTEs), and mixed populations of nHBEs and nHTEs (nHAEs) (Cottrill et al., 2021; Stauffer et al., 2017).