FISH testing for ALK gene rearrangements using the Vysis ALK break-apart FISH probe kit (Abbott Molecular) was performed in a total of 14 randomly selected cases (7 ALK ICC positive cases and 7 ALK ICC negative cases). ALK rearrangements by the FISH technique could be detected in 5/7 (71.4%) cases, which were positive on ALK ICC. The gene discussed is ALK; the disease is intrahepatic cholangiocarcinoma.