ALK and intrahepatic cholangiocarcinoma: The prevalence of ALK rearrangements using FISH and IHC observed in the present study is in concordance with other studies wherein the prevalence ranged from 3 to 14.9% and 4 to 15.4%, for FISH and IHC, respectively. The concordance rates of ALK IHC and ALK-FISH in the published literature are variable and range from 75-100% (Table 3). The concordance rate between ICC and FISH in the present study was 66.7%.