Gene Ontology Biological Process term enrichment analysis for each differentially expressed protein cluster revealed apparent downregulation of GABAergic synaptic activity (Cluster 1; GABRA1, GABRA2, GABRD, GRIA3) and upregulation of pro-inflammatory glycolytic metabolism (Cluster2; HK1, ALDOA, PGK1, PGM1) in DLB EV (Fig. 5c, d). The gene discussed is PGK1; the disease is Lewy body dementia.