CAPN1 and Lewy body dementia: The DLB GBA wild-type EV sample did not show the characteristic cleavage pattern on NMR; however, the proteomic analysis showed an upregulation of proteases mainly involved in cellular maintenance, such as subunits of the ubiquitin–proteasome system, several mitochondrial proteases (e.g. calpain 1), and oxidative stress response/alpha-synuclein chaperone activity (PARK7/DJ1) [7, 94] (Online Resource Fig. 10).