For example, miR-939 has been shown to regulate proinflammatory genes such as IL-6 and nitric oxide synthase, which are often increased in patients with CRPS.30,37 Specifically, miR-939 was only increased in B cells isolated from patients with CRPS whole blood, and a functional role of CD20+ B cells in the TFM has been demonstrated in mice, suggesting therapies targeting B-cell–mediated pathways may be beneficial.37 Although not significant, our data found a change in the miR-939 expression in sEVs of TFM mice (data not shown), suggesting it may still play a mechanistic role in both models. This evidence concerns the gene IL6 and complex regional pain syndrome.