LYN and gastric cancer: In order to elucidate whether miR-496 exerts tumor suppressive effect in gastric cancer through LYN, we transfected miR-496 mimics and LYN overexpression plasmid (miR-496 & LYN) in AGS cell line at the same time (Figure 4a), and detected the cell proliferation and apoptosis with miR-496 mimics as a control.