NFE2L2 and digestive system neoplasm: Zhang et al. [12] found that when the left cervical vagal trunk (the origin of the hepatic vagus nerve) was stimulated with a high-frequency electrode, the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) was markedly increased, which alleviated liver IRI by inhibiting oxidative stress, inflammation, and apoptosis in the liver.