This view was also confirmed by the establishment of a predictive survival model for ccRCC patients with nine CBRGs, including SQLE and CYP51A1. After this, Clayman et al. [19] also put forward the view that mutations of SQLE, HMGCR, and other genes could affect cholesterol metabolism, thus further affecting cancer, and the conclusion is put forward. This evidence concerns the gene HMGCR and cancer.