In addition, Yao Y et al. discovered that exosomes derived from platelets of the atherosclerosis models of ApoE-/- mice exhibited high expression level of miR-25-3p which could target Adam 10 and reduce its expression in the ox-LDL-treated coronary vascular endothelial cells (CVECs), leading to the attenuation of CVEC inflammation (81). Here, APOE is linked to atherosclerosis.