KLF5 and atherosclerosis: Zheng et al. found that vascular smooth muscle cell-derived exosomes mediate the transfer of Krüppel-like factor 5-induced miR-155 from smooth muscle cells to endothelial cells, damaging the tight junction of endothelial cells and the integrity of barriers leading to increased endothelial cell permeability and accelerating atherosclerosis (76).