In Model 3, after adjusting for age, BMI, number of drugs, CCI, heart failure, RBC, albumin, total cholesterol, triglyceride, LDL-C and HDL-C, lower RDW (β = −0.721, P = 0.033) was a protective factor for frailty, while lower HRR (β =1.126, P = 0.004) was a risk factor for frailty (Table 5). This evidence concerns the gene ALB and heart failure.