GAL and myocardial infarction: The hypothesized Stage 3 in Figure 1 suggests that following the Fc/Fc receptor interactions between the recruited macrophages and anti-Gal coated α-gal nanoparticles in injured myocardium, the macrophages polarize into pro-reparative macrophages that secrete cytokines which, similar to their effects in wound healing, enhance repair and restore the normal structure and function of the post-MI myocardium.