Anti-atherosclerosis processes might include the regulation of miRNAs expression of EPC-EXs; decrease of the levels of oxidative stress factors malondialdehyde (MDA) and superoxide dismutase (SOD) and the inflammatory factors ICAM-1, IL-8, and C-reactive protein (CRP); and the change of high K+ solution- and Phe-induced vasoconstriction and endothelium-dependent vasodilation in the thoracic aorta (94). The gene discussed is CRP; the disease is atherosclerosis.