Based on the multivariable regression analysis, age (OR = 1.255; 95% CI 1.199–1.313), fasting glucose (OR = 0.824; 95% CI, 0.702–0.968), HbA1c (OR = 1.542; 95% CI, 1.171–2.031), HDL (OR = 0.142; 95% CI, 0.045–0.443), BUN (OR = 1.270; 95% CI, 1.032–1.563), and GLP-1 (OR = 0.889; 95% CI, 0.844–0.936) were independently associated with CAVD risk (Model 1 in Table 3). Here, GCG is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.