Nevertheless, HMGA2 is re-expressed in many types of cancer (Mansoori et al., 2021), and it could manipulate tumorigenesis, metastasis, and relapse via participating in cell cycle, apoptosis, angiogenesis, epithelial–mesenchymal transition, and chemoresistance (Zhao et al., 2018; Wu et al., 2019; Li et al., 2020a; Mansoori et al., 2020). Here, HMGA2 is linked to cancer.