In whole grade glioma of the CGGA and TCGA, Circos plots based on the Pearson r value revealed that LIGHT expression was significantly associated with these immune checkpoint members, especially HVEM, PD1/PD-L1 pathway, TIM-3, and B7-H3 (Figures 3A–D). The gene discussed is TNFRSF14; the disease is glioma.