The aim is to illustrate involvement of dysregulated IL-37 and IL-38 in gestational diabetes mellitus (GDM) and pre-eclampsia, which are two rather common and closely linked complications during pregnancy (1–3), i.e., there is a substantially high prevalence of pre-eclampsia among women with hyperglycaemia either short term (GDM) or long term (DM). This evidence concerns the gene IL37 and Hyperglycemia.