IL37 and gestational diabetes: In addition, there is differential regulation of IL-37 and IL-38 in the placenta from GDM subjects (45), which parallels the observations from colorectal cancers (34, 53, 54), thus inviting speculation that IL-38 would be also be regulated to participate in the local immunopathological-mediated condition in pre-eclampsia subjects for reducing the immune response, perhaps via releasing IL-38 from apoptotic cells to limit inflammatory macrophage responses (35).