Furthermore, IFN-β-secreting BMMSCs (BMMSC-IFN-β) in addition to the induction of reduced cell proliferation and G1-phase arrest in HCC cell line HepG2 and Huh7 in vitro, suppressed tumor growth in HCC NOD/SCID mice model. This evidence concerns the gene IFNB1 and hepatocellular carcinoma.