AKT1 and glioblastoma: On the other hand, it was found that combine treatment of MSC-TRAIL and paclitaxel (121) or with AKT inhibitors (122) or with VPA (52) triggered apoptosis in human pancreatic carcinoma (CFPAC-1) (54), glioblastoma (U87-MG) (121), prostate cancer (PC3, LNCaP, and C4-2B) (122), and in glioblastoma (U87 and U138) (52) cell lines in vitro, respectively.