For instance, MSC-IL-21 systemic injection into the B-cell lymphoma A20 cell-bearing BALB/c mice resulted in delayed tumor occurrence and also prolonged survival, while either MSCs or recombinant adenovirus-expressing IL-21 (rAD/IL-21) could not induce desirable antitumor effects in experimental models (76). Here, IL21 is linked to B-cell non-Hodgkin lymphoma.