Interestingly, adjusted models for age, sex, BK, JC and HIV viremia (models 2 and 3, respectively) did not change the association of 2 APOL RRA with CKD while adjustment for APOL1 RRA*HIV interaction (model 4) increased the OR for 1 and 2 APOL1 RRA significantly (Table 4). Here, APOL1 is linked to chronic kidney disease.