POSTN is also capable of activating canonical Wnt/β-catenin signaling in BMSCs and chondrocytes, resulting in induced MMP13 and ADAMTS4 expression to accelerate the pathogenesis of OA, and mediates estrogen-induced osteogenic differentiation of BMSCs in ovariectomized rats to reduce osteoporosis (60, 61, 109). The gene discussed is POSTN; the disease is osteoporosis.