TH and Hand-foot syndrome: Compared with the telogen phase, the formation of sympathetic adrenergic and tyrosine hydroxylase (TH) nerve fibers in the dermis and subcutaneous tissue of synchronized HFs increased sharply in the early anagen phase, but decreased steeply in the catagen phase (Botchkarev et al., 1999; Slominski et al., 1999; Kim et al., 2011)—TH antigen is a specific marker of adrenergic nerves (Ljungberg and Johansson, 1993).