For TP53, such mutation pattern has been recognized in multiple tumor types, especially for head and neck cancer (Boyle et al., 1993) and lung cancer (Veldore et al., 2015), rather than other malignant proliferative diseases, such as esophageal adenocarcinoma and melanoma; this finding reflects the distinctive potentials of such mutation pattern. This evidence concerns the gene TP53 and esophageal adenocarcinoma.