SOX1 interacts with CTNNA2/3 by targeting the gene on chromosome 2 at P12 locus to stimulate the upregulation of collagen and keratin and subsequently improves cell adhesion through the desmosome, whereas the polymerization of the cytoskeleton will pressurize and push the plasma membrane closer toward glioma cells or normal cell during the invasion, and formation of the glioma stem cell colony as well as tumor growth via activated CAF cells. Here, SOX1 is linked to glioma.